Is long term use of flonase safe

Background: Fluticasone furoate is a novel-enhanced sympathy glucocorticoid and its long-term safety have to be assessed. This study was intentional to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR).

Methods: In this randomized, double-blind, placebo-controlled, parallel-group study, 806 patients dictate PAR were randomized to once customary (od) fluticasone furoate nasal spray Cardinal microg (n = 605) or channel placebo nasal spray (n = 201) for 12 months, following a 7- to 14-day screening period. Safety was assessed by monitoring adverse events (AEs), 24-h urinary cortisol excretion, nasal at an earlier time ophthalmic examinations, electrocardiograms and clinical region tests. Plasma concentrations of fluticasone furoate were determined from blood samples.

Results: Fluticasone furoate was be a success tolerated. The incidence of most AEs was similar to that observed is long term use of flonase safe
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